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Peter Pyrko Selected Research

Endoplasmic Reticulum Chaperone BiP

2/2008Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib.
10/2007The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.
9/2007Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib.
4/2007Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.

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Peter Pyrko Research Topics

Disease

6Neoplasms (Cancer)
02/2008 - 09/2005
3Glioblastoma (Glioblastoma Multiforme)
02/2008 - 09/2007
3Glioma (Gliomas)
11/2007 - 09/2005
1Residual Neoplasm
10/2007
1Hypoxia (Hypoxemia)
09/2007

Drug/Important Bio-Agent (IBA)

4Endoplasmic Reticulum Chaperone BiPIBA
02/2008 - 04/2007
4Celecoxib (Celebrex)FDA Link
02/2008 - 05/2006
4Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
02/2008 - 05/2006
32,5-dimethylcelecoxibIBA
02/2008 - 04/2007
3Small Interfering RNA (siRNA)IBA
02/2008 - 04/2007
3Proteins (Proteins, Gene)FDA Link
11/2007 - 04/2007
3Pharmaceutical PreparationsIBA
09/2007 - 05/2006
2Irinotecan (Camptosar)FDA LinkGeneric
10/2007 - 05/2006
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
09/2007 - 05/2006
2SurvivinIBA
09/2007 - 05/2006
2Apoptosis Regulatory ProteinsIBA
09/2007 - 05/2006
1Drug CombinationsIBA
02/2008
1Bortezomib (Velcade)FDA Link
02/2008
1Protease Inhibitors (Protease Inhibitor)IBA
11/2007
1Proteasome Endopeptidase Complex (Proteasome)IBA
11/2007
1Atazanavir Sulfate (Reyataz)FDA Link
11/2007
1Human immunodeficiency virus 1 p16 proteaseIBA
11/2007
1Nelfinavir (Viracept)FDA Link
11/2007
1Caspase 7IBA
10/2007
1epigallocatechin gallate (epigallocatechin-3-gallate)IBA
10/2007
1Temozolomide (Temodar)FDA LinkGeneric
10/2007
1Adenosine Triphosphate (ATP)IBA
10/2007
1Fluorouracil (Carac)FDA LinkGeneric
10/2007
1cobaltous chloride (cobalt(II)chloride)IBA
09/2007
1Glucose (Dextrose)FDA LinkGeneric
09/2007
1CalciumIBA
04/2007
1Snake Venoms (Snake Venom)IBA
09/2005
1contortrostatinIBA
09/2005
1IntegrinsIBA
09/2005
1DisintegrinsIBA
09/2005

Therapy/Procedure

3Drug Therapy (Chemotherapy)
10/2007 - 09/2005
1Therapeutics
09/2005